Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.38 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.38 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.38 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274658 | 0.93 | KDM4E (0.55) | KDM4EALDH1A1EGLN2CA1CA2 | |
| SCHEMBL29757148 | 0.93 | KDM4E (0.55) | KDM4EALDH1A1EGLN2CA1CA2 | |
| Hydrochloric Acid SCHEMBL31491126 | 0.92 | KDM4E (0.53) | KDM4EALDH1A1EGLN2CA1CA2 | |
| Hydrochloric Acid SCHEMBL4734485 | 0.92 | KDM4E (0.53) | KDM4EALDH1A1EGLN2CA1CA2 | |
| SCHEMBL10481543 | 0.78 | ERCC5 (0.60) | KDM4EALDH1A1PARP1POLBMAPT | |
| SCHEMBL7446526 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1EGLN2CA1CA2 | |
| SCHEMBL24229642 | 0.76 | HDAC8 (0.55) | KDM4EPARP1POLBMAPTCTNNB1 | |
| Sulfuric Acid SCHEMBL20838235 | 0.75 | CA12 (0.55) | KDM4EALDH1A1EGLN2CA1CA2 | |
| Hydrochloric Acid SCHEMBL11756049 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1EGLN2CA1CA2 | |
| SCHEMBL2292351 | 0.75 | CES2 (0.55) | KDM4EALDH1A1PARP1MAPTCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118016943-A | High-energy-density alkaline iron-sulfur flow battery and preparation method thereof | 北京民利储能技术有限公司 | 2024-05-10 | — | — | CN | claimed |
| US-12480100-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| US-20240301366-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | CODEXIS INC (US) | 2024-09-12 | — | — | US | disclosed |
| US-12031159-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| CN-118016943-A | High-energy-density alkaline iron-sulfur flow battery and preparation method thereof | 北京民利储能技术有限公司 | 2024-05-10 | — | — | CN | disclosed |
| US-20220267744-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2022-08-25 | — | — | US | disclosed |
| US-11345898-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210062162-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2021-03-04 | — | — | US | disclosed |
| US-10870835-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20200157511-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-05-21 | — | — | US | disclosed |
| US-10358631-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180066239-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-03-08 | — | — | US | disclosed |
| EP-2467473-B1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | CODEXIS INC (US) | 2016-03-23 | — | — | EP | disclosed |
| US-9102959-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | CODEXIS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20120149073-A1 | Ketoreductase Polypeptides for the Preparation of Phenylephrine | CODEXIS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2009086283-A1 | SYNTHESIS OF ENANTIOMERICALLY PURE 2-HYDROXY-2-ARYL-ETHYLAMINES | CAMBREX CHARLES CITY, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12031159-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-20220267744-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-20180066239-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-20210062162-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-20200157511-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-10870835-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-12480100-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-20240301366-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-10358631-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
| US-11345898-B2 | Ketoreductase polypeptides for the preparation of phenylephrine | AKR1B1, AKR1A1, AKR1C2 | ADRB2 50/4885ADRB1 34/4885ADRA2A 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.