Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.50 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.48 |
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.46 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.41 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.41 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.41 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.41 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31491126 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1EGLN2CA12CA1 | |
| SCHEMBL29757148 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1EGLN2CA12CA1 | |
| SCHEMBL1274658 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1EGLN2CA12CA1 | |
| Sulfuric Acid SCHEMBL4016436 | 0.92 | KDM4E (0.49) | KDM4EALDH1A1EGLN2CA12CA1 | |
| Hydrochloric Acid SCHEMBL11756049 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1EGLN2CA12CA1 | |
| Hydrochloric Acid SCHEMBL15973303 | 0.81 | CES2 (0.53) | KDM4EALDH1A1PARP1MAPTCTNNB1 | |
| SCHEMBL7446526 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1EGLN2CA12CA1 | |
| SCHEMBL24229642 | 0.80 | HDAC8 (0.55) | KDM4EPARP1MAPTCTNNB1LMNA | |
| Hydrochloric Acid SCHEMBL259354 | 0.79 | KMT2A (0.60) | KDM4EALDH1A1GAAMAPTHIF1A | |
| SCHEMBL10481543 | 0.79 | ERCC5 (0.60) | KDM4EALDH1A1PARP1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921197-A | Preparation method of phenylephrine | WEIFANG HAPPY PHARMACEUTICAL LTD | 2010-12-22 | — | — | CN | claimed |
| US-20250312270-A1 | READY-TO-INFUSE PHENYLEPHRINE COMPOSITIONS | AMNEAL EU, LIMITED (IE) | 2025-10-09 | — | — | US | disclosed |
| WO-2025059259-A1 | NEW PROCESS FOR PHENYLEPHRINE AND SALBUTAMOL AND RELATED COMPOUNDS VIA ASYMETRIC TRANSFER HYDROGENATION OF UNPROTECTED AMINO KETONES | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2025-03-20 | — | — | WO | disclosed |
| US-20250025409-A1 | READY-TO-INFUSE PHENYLEPHRINE COMPOSITIONS | AMNEAL EU, LIMITED (IE) | 2025-01-23 | — | — | US | disclosed |
| US-20210228507-A1 | Phenylephrine Hydrochloride Compositions and Containers | NEVAKAR INC. (US) | 2021-07-29 | — | — | US | disclosed |
| CN-102234237-B | Method for preparing L-phenylephrine hydrochloride | CHIFENG ARKER PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-03-26 | — | — | CN | disclosed |
| CN-102234237-A | Method for preparing L-phenylephrine hydrochloride | CHIFENG ARKER PHARMACEUTICAL TECHNOLOGY CO LTD | 2011-11-09 | — | — | CN | disclosed |
| CN-201791519-U | Deoxidation adrenergic hydrogenation device | WEIFANG HAPPY PHARMACEUTICAL CO LTD | 2011-04-13 | — | — | CN | disclosed |
| CN-101921197-A | Preparation method of phenylephrine | WEIFANG HAPPY PHARMACEUTICAL LTD | 2010-12-22 | — | — | CN | disclosed |
| WO-2008095678-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS | LONZA AG (CH) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008077560-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS | LONZA AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250312270-A1 | READY-TO-INFUSE PHENYLEPHRINE COMPOSITIONS | REN, PEF1, AVPR2 | CA2 1767/4885PARP1 4581/4885GAA 3612/4885 |
| US-20250025409-A1 | READY-TO-INFUSE PHENYLEPHRINE COMPOSITIONS | REN, PEF1, AVPR2 | CA2 1767/4885PARP1 4581/4885GAA 3612/4885 |
| US-20210228507-A1 | Phenylephrine Hydrochloride Compositions and Containers | ADRA1A, ADRA2C, ADRB1 | CA2 1277/4885PARP1 1804/4885GAA 1789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.