Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20169248 | 0.88 | ALDH1A1 (0.58) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL9573784 | 0.84 | LMNA (0.52) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL9744204 | 0.81 | CLCN2 (0.45) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL8196433 | 0.81 | LMNA (0.72) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL16887793 | 0.81 | ALDH1A1 (0.61) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL13541679 | 0.81 | ALDH1A1 (0.54) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL21935935 | 0.81 | SMN1; SMN2 (0.50) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL8540162 | 0.79 | GLA (0.49) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL7802433 | 0.78 | LMNA (0.61) | MAPTALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL5445479 | 0.78 | POLB (0.66) | MAPTALDH1A1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482365-B2 | 4-(2,2-Dimethyl-propylamino)-2-(4-fluoro-2-methyl-phenyl)-piperidine-1-carboxylic acid, [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide; specific antagonists of tachykinins receptor: substance P and neurokinins (NK1); antidepressant, anxiolytic agent; serotonin receptor inhibitor | GLAXO GROUP LIMITED (GB) | 2009-01-27 | — | — | US | disclosed |
| US-20050171153-A1 | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases | GLAXO GROUP LIMITED (GB) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171153-A1 | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases | NPSR1, NPY1R, NPY2R | MAPT 2288/4885ALDH1A1 2635/4885KMT2A 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.