Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 9/20 | 0.38 |
| ▸ | AKT2 | P31751 | 9/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017685 | 0.84 | ADRB2 (0.34) | AKT1JAK2 | |
| SCHEMBL4017146 | 0.80 | LMNA (0.40) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| SCHEMBL4014441 | 0.73 | SMN1; SMN2 (0.47) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| SCHEMBL4016468 | 0.73 | CYP1A2 (0.44) | AKT1AKT2AKT3MALT1 | |
| SCHEMBL4017662 | 0.72 | SUV39H1 (0.48) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| SCHEMBL4018922 | 0.64 | LMNA (0.45) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| SCHEMBL4019437 | 0.64 | GPR119 (0.42) | AKT1 | |
| SCHEMBL29230268 | 0.63 | LMNA (0.59) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL2797475 | 0.63 | LMNA (0.65) | LMNAHTTSMN1; SMN2AKT1AKT2 | |
| SCHEMBL2795640 | 0.62 | LMNA (0.64) | LMNAHTTSMN1; SMN2AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |