Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 12/20 | 0.78 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939849 | 0.89 | FAAH (0.98) | FAAHKDM2B | |
| SCHEMBL4014996 | 0.88 | FAAH (0.70) | FAAHTHRBGAAKDM4E | |
| SCHEMBL3936930 | 0.88 | FAAH (1.00) | FAAHKDM2BTP53KDM4ENPC1 | |
| SCHEMBL3932151 | 0.86 | FAAH (0.83) | FAAHKDM2B | |
| SCHEMBL3933967 | 0.86 | FAAH (0.83) | FAAHKDM4ENPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL4012253 | 0.85 | FAAH (0.68) | FAAHTP53KDM4ENPC1RAB9A | |
| SCHEMBL4012669 | 0.80 | FAAH (0.79) | FAAHABCB1ABCG2 | |
| SCHEMBL3936220 | 0.80 | FAAH (1.00) | FAAHTP53NPC1RAB9AMAPT | |
| SCHEMBL3929528 | 0.80 | FAAH (0.85) | FAAHABCB1ABCG2 | |
| SCHEMBL4017519 | 0.79 | FAAH (0.76) | FAAHABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |