Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247716 | 0.92 | LMNA (0.41) | LMNANPC1RAB9APIK3CD | |
| SCHEMBL4027824 | 0.86 | LMNA (0.45) | LMNANPC1RAB9AKDM4EGAA | |
| SCHEMBL4025575 | 0.84 | LMNA (0.51) | LMNANPC1RAB9AKDM4EGAA | |
| SCHEMBL1447382 | 0.83 | LMNA (0.54) | LMNANPC1RAB9AKDM4EGAA | |
| SCHEMBL4251064 | 0.82 | LMNA (0.52) | LMNANPC1RAB9AKDM4EGAA | |
| SCHEMBL4248375 | 0.70 | LMNA (0.31) | LMNA | |
| SCHEMBL4021989 | 0.67 | TRPM8 (0.36) | LMNA | |
| SCHEMBL4509021 | 0.67 | LMNA (0.39) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL4491202 | 0.66 | LMNA (0.41) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL1447361 | 0.66 | LMNA (0.41) | LMNARAB9AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |