Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594480 | 0.82 | ALDH1A1 (0.34) | LMNA | |
| SCHEMBL1448022 | 0.75 | LMNA (0.37) | LMNACHRNA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4027824 | 0.73 | LMNA (0.45) | LMNACHRNA4S1PR1S1PR3TAS1R3 | |
| SCHEMBL4247716 | 0.71 | LMNA (0.41) | LMNACHRNA4S1PR1S1PR3TAS1R3 | |
| SCHEMBL1447382 | 0.71 | LMNA (0.54) | TRPM8LMNACHRNA4S1PR1S1PR3 | |
| SCHEMBL4251064 | 0.70 | LMNA (0.52) | TRPM8LMNAS1PR1S1PR3TAS1R3 | |
| SCHEMBL4027100 | 0.70 | LMNA (0.37) | LMNACHRNA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3557090 | 0.69 | SMN1; SMN2 (0.37) | LMNA | |
| SCHEMBL4020643 | 0.67 | LMNA (0.37) | LMNA | |
| SCHEMBL6593091 | 0.66 | MLYCD (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |