Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027984 | 0.92 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4023645 | 0.91 | KDM2B (0.39) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4028155 | 0.90 | KMT2A (0.34) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4025103 | 0.90 | KDM2B (0.41) | KMT2AMEN1KDM4EALDH1A1SLC6A1 | |
| SCHEMBL4019728 | 0.89 | TAS1R3 (0.36) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4020327 | 0.87 | CPS1 (0.39) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL4749432 | 0.85 | CYP2D6 (0.34) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4027216 | 0.84 | KMT2A (0.41) | KMT2AMEN1ALDH1A1MC4R | |
| SCHEMBL4019668 | 0.83 | HRH2 (0.34) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL4020633 | 0.83 | MEN1 (0.35) | KMT2AMEN1OPRM1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |