Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027984 | 0.93 | TAS1R3 (0.37) | TAS1R3TAS1R1TAS1R2MC4RHCRTR1 | |
| SCHEMBL4027024 | 0.93 | HTR2A (0.35) | TAS1R3TAS1R1TAS1R2PIN1HTR2A | |
| SCHEMBL4029269 | 0.92 | KDM2B (0.35) | TAS1R3TAS1R1TAS1R2MGLLHRH2 | |
| SCHEMBL4022304 | 0.89 | TAS1R3 (0.39) | TAS1R3TAS1R1TAS1R2MC4RHCRTR1 | |
| SCHEMBL4028177 | 0.89 | CARM1 (0.35) | TAS1R3TAS1R1TAS1R2MGLLHRH2 | |
| SCHEMBL4024780 | 0.86 | KDM4E (0.34) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4019668 | 0.86 | HRH2 (0.34) | TAS1R3TAS1R1TAS1R2MC4RMGLL | |
| SCHEMBL4027811 | 0.86 | KDM1A (0.34) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4023645 | 0.85 | KDM2B (0.39) | TAS1R3TAS1R1TAS1R2MC4RMEN1 | |
| SCHEMBL4749430 | 0.85 | KIF11 (0.35) | TAS1R3TAS1R1TAS1R2MGLLHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |