Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752708 | 0.87 | MEN1 (0.43) | CYP2D6TAAR1HCRTR1HCRTR2MEN1 | |
| SCHEMBL4022304 | 0.85 | TAS1R3 (0.39) | CYP2D6TAAR1MC4RHCRTR1HCRTR2 | |
| SCHEMBL4749424 | 0.85 | EED (0.42) | CYP2D6TAAR1 | |
| SCHEMBL4749426 | 0.85 | EED (0.42) | CYP2D6TAAR1 | |
| SCHEMBL4749102 | 0.84 | POLB (0.36) | MC4RMEN1KMT2A | |
| SCHEMBL4027216 | 0.83 | KMT2A (0.41) | MC4RMEN1KMT2A | |
| SCHEMBL4027984 | 0.83 | TAS1R3 (0.37) | MC4RHCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL4020633 | 0.82 | MEN1 (0.35) | MC4RMEN1KMT2A | |
| SCHEMBL4019728 | 0.82 | TAS1R3 (0.36) | CYP2D6TAAR1MC4RHCRTR1HCRTR2 | |
| SCHEMBL4023645 | 0.82 | KDM2B (0.39) | MC4RMEN1KMT2ATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |