Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13504568 | 0.92 | HTR6 (0.48) | HTR6LMNASMN1; SMN2PLK1DRD2 | |
| Trifluoroacetic Acid SCHEMBL4020079 | 0.83 | HTR6 (0.55) | HTR6LMNAFABP4MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL3617242 | 0.78 | HTR6 (0.55) | HTR6LMNASMN1; SMN2TNFDRD2 | |
| Trifluoroacetic Acid SCHEMBL4020301 | 0.77 | FABP4 (0.56) | HTR6FABP4 | |
| Trifluoroacetic Acid SCHEMBL3621154 | 0.76 | HTR6 (0.56) | HTR6 | |
| Trifluoroacetic Acid SCHEMBL4018381 | 0.75 | HTR6 (0.48) | HTR6LMNA | |
| Trifluoroacetic Acid SCHEMBL743223 | 0.72 | HTR6 (0.53) | HTR6LMNASMN1; SMN2PLK1MEN1 | |
| SCHEMBL4785309 | 0.72 | HTR6 (0.43) | HTR6LMNASMN1; SMN2PLK1MEN1 | |
| SCHEMBL3619076 | 0.72 | HTR6 (0.52) | HTR6LMNASMN1; SMN2PLK1MEN1 | |
| Trifluoroacetic Acid SCHEMBL5874682 | 0.70 | KDM4E (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |