Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480554 | 0.92 | ALDH1A1 (0.59) | ALDH1A1LMNAL3MBTL1KDM4EPKM | |
| SCHEMBL6492319 | 0.92 | ALDH1A1 (0.59) | ALDH1A1LMNAL3MBTL1KDM4EPKM | |
| SCHEMBL4031087 | 0.92 | ALDH1A1 (0.59) | ALDH1A1LMNAL3MBTL1KDM4EPKM | |
| SCHEMBL4034013 | 0.86 | ALDH1A1 (0.58) | ALDH1A1PKM | |
| SCHEMBL4029144 | 0.86 | ALDH1A1 (0.58) | ALDH1A1PKM | |
| SCHEMBL19426808 | 0.83 | AGTR2 (0.52) | ALDH1A1LMNAKDM4ENPC1AKR1C3 | |
| SCHEMBL4028682 | 0.83 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL4034942 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAL3MBTL1KDM4EPKM | |
| SCHEMBL6493434 | 0.79 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL14575007 | 0.79 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1452527-B1 | AZABICYCLO COMPOUND, MATRIX METALLOPROTEASE INHIBITOR, AND SKIN PREPARATION | SHISEIDO CO LTD (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-7176217-B2 | Azabicyclo compound matrix metalloprotease inhibitor and skin preparation | SHISEIDO CO., LTD. (JP) | 2007-02-13 | — | — | US | disclosed |
| US-20050009808-A1 | Azabicyclo compound matrix metalloprotease inibitor and skin preparation | SHISEIDO CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| EP-1452527-A1 | AZABICYCLO COMPOUND, MATRIX METALLOPROTEASE INHIBITOR, AND SKIN PREPARATION | Shiseido Co., Ltd. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009808-A1 | Azabicyclo compound matrix metalloprotease inibitor and skin preparation | MMP1, MMP16, MMP9 | ALDH1A1 1160/4885LMNA 2771/4885L3MBTL1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.