Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026364 | 0.78 | KDM4E (0.35) | ALDH1A1KDM4ESMN1; SMN2GAAHPGD | |
| SCHEMBL4024972 | 0.77 | ADORA3 (0.39) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL4026347 | 0.75 | CDC7 (0.46) | L3MBTL1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4026168 | 0.75 | KDM5B (0.42) | L3MBTL1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4031544 | 0.74 | KDM5B (0.45) | L3MBTL1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL22927688 | 0.73 | CYP19A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29434810 | 0.73 | LMNA (0.43) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL4030138 | 0.72 | ERCC1 (0.57) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL27275782 | 0.72 | KDM5B (0.40) | L3MBTL1ALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL4025043 | 0.71 | GABRA1 (0.45) | ALDH1A1KDM4EADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | disclosed |
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2005-06-16 | — | — | US | disclosed |
| EP-1470113-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062211-A1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | POLR2A, POLR1E, POLR2E | L3MBTL1 3083/4885ALDH1A1 255/4885KDM4E 2458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.