Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823508 | 0.87 | FOLH1 (0.57) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL9169708 | 0.84 | L3MBTL1 (0.50) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL30147524 | 0.84 | MAPT (0.65) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL18428699 | 0.84 | MAPT (0.65) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL9808151 | 0.83 | ALDH1A1 (0.55) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL18428719 | 0.82 | HPGDS (0.64) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C9 | |
| SCHEMBL514323 | 0.81 | L3MBTL1 (0.50) | L3MBTL1MAPTSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL416462 | 0.81 | MAPT (0.57) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C19 | |
| SCHEMBL29380769 | 0.81 | MAPT (0.57) | L3MBTL1MAPTMRGPRX4SMN1; SMN2CYP2C19 | |
| SCHEMBL5232608 | 0.81 | CNR2 (0.53) | L3MBTL1MAPTSMN1; SMN2CYP2C9CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |