Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MDH2 | P40926 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NMT1 | P30419 | 4/20 | 0.56 |
| ▸ | NMT2 | O60551 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906659 | 0.92 | GABRA1 (0.71) | TRPM8GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL2811774 | 0.91 | ALDH1A1 (0.66) | TRPM8GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL11620503 | 0.89 | TRPM8 (0.61) | TRPM8GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL9023222 | 0.88 | NR4A2 (0.66) | TRPM8MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL28123392 | 0.86 | TRPM8 (0.60) | TRPM8MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL6764594 | 0.85 | MAOB (0.61) | TRPM8MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL4176704 | 0.85 | MDH2 (0.76) | GABRA1GABRA3MEN1KMT2AGABRB2 | |
| SCHEMBL4976948 | 0.85 | ALDH1A1 (0.56) | TRPM8MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL853558 | 0.83 | TRPM8 (0.55) | TRPM8GABRA1GABRA3GABRG2GABRB3 | |
| SCHEMBL11602121 | 0.83 | ALDH1A1 (0.61) | TRPM8MEN1KMT2AHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171428-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2009-06-17 | — | — | EP | disclosed |
| EP-1171428-A4 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2004-09-15 | — | — | EP | disclosed |
| US-6765005-B2 | BACTERICIDES; ENZYME INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-07-20 | — | — | US | disclosed |
| US-20030139377-A1 | Fab I inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-07-24 | — | — | US | disclosed |
| US-6503903-B1 | Administering 3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carboxamide derivative | SMITHKLINE BEECHAM CORPORATION | 2003-01-07 | — | — | US | disclosed |
| EP-1171428-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063187-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139377-A1 | Fab I inhibitors | SERPINB1, TFPI, TFPI2 | TRPM8 4452/4885GABRA1 1916/4885GABRA3 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.