Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037282 | 0.83 | MAPT (0.52) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL4029460 | 0.81 | NPSR1 (0.61) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL7763901 | 0.81 | KMT2A (0.51) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL9903838 | 0.80 | NPSR1 (0.48) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL4028725 | 0.80 | MAPT (0.49) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL4030354 | 0.78 | MAPT (0.48) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL4032659 | 0.78 | NPSR1 (0.52) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL4032674 | 0.76 | LPAR1 (0.51) | KMT2AMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL28635457 | 0.75 | PTGS2 (0.69) | KMT2ALMNACA1CA2CA4 | |
| SCHEMBL27969142 | 0.75 | GABRA5 (0.51) | KMT2AMAPTKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |