Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029460 | 0.89 | NPSR1 (0.61) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL4028725 | 0.88 | MAPT (0.49) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL9903838 | 0.88 | NPSR1 (0.48) | MAPTKDM4ENPSR1RAB9ATSHR | |
| SCHEMBL4032659 | 0.85 | NPSR1 (0.52) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL4030815 | 0.83 | KMT2A (0.54) | MAPTKDM4ENPSR1RAB9ATSHR | |
| SCHEMBL4036524 | 0.81 | NTRK1 (0.56) | MAPTNPSR1NTRK1KMT2AMEN1 | |
| SCHEMBL5527223 | 0.78 | MEN1 (0.61) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL17790727 | 0.77 | MAPT (0.60) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL4032643 | 0.77 | TSHR (0.51) | MAPTKDM4ENPSR1TSHRHTT | |
| SCHEMBL4034243 | 0.77 | KMT2A (0.49) | MAPTKDM4ENPSR1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |