Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027437 | 0.83 | FEN1 (0.57) | FEN1ERCC1ERCC4LMNAMAPT | |
| SCHEMBL4027681 | 0.82 | ERCC1 (0.41) | FEN1ERCC1ERCC4POLBALDH1A1 | |
| SCHEMBL4029257 | 0.82 | FEN1 (0.44) | FEN1ERCC1ERCC4POLBALDH1A1 | |
| SCHEMBL4028581 | 0.81 | ERCC1 (0.44) | FEN1ERCC1ERCC4LMNAALDH1A1 | |
| SCHEMBL4031571 | 0.80 | ERCC1 (0.40) | FEN1ERCC1ERCC4ALDH1A1MAPT | |
| SCHEMBL4028019 | 0.79 | FEN1 (0.39) | FEN1ERCC1ERCC4 | |
| SCHEMBL4028795 | 0.76 | ERCC1 (0.39) | FEN1ERCC1ERCC4LMNAPOLB | |
| SCHEMBL4026147 | 0.76 | FEN1 (0.39) | FEN1ERCC1ERCC4LMNAALDH1A1 | |
| SCHEMBL4028118 | 0.75 | ERCC1 (0.40) | FEN1ERCC1ERCC4ALDH1A1RXFP1 | |
| SCHEMBL4032043 | 0.75 | ERCC1 (0.67) | FEN1ERCC1ERCC4LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |