Alcohol

Alcohol

SCHEMBL4031818

CCO.COc1ccc2cc(N)c(=O)oc2c1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.59
HPGD P15428 5/20 0.59
KDM4E B2RXH2 5/20 0.59
GAA P10253 3/20 0.59
CA12 O43570 3/20 0.59
CA9 Q16790 3/20 0.59
MAOB P27338 3/20 0.59
GLA P06280 3/20 0.59
CA2 P00918 3/20 0.59
CA3 P07451 2/20 0.59
CA4 P22748 2/20 0.59
CA6 P23280 2/20 0.59
CA7 P43166 2/20 0.59
CA14 Q9ULX7 2/20 0.59
CYP2C19 P33261 1/20 0.59
SLC16A3 O15427 1/20 0.58
RAB9A P51151 5/20 0.57
NPC1 O15118 4/20 0.57
CA1 P00915 2/20 0.57
MEN1 O00255 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4041859 0.93 CA12 (0.64) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL8756380 0.82 GLA (0.64) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL11405408 0.80 CA2 (0.64) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL18474355 0.80 CA9 (0.65) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL11618512 0.79 GPR55 (0.67) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL12523188 0.79 GPR55 (0.70) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL23350788 0.79 ALDH1A1 (0.56) ALDH1A1HPGDKDM4EGAAMAOB
SCHEMBL7884546 0.78 KDM4E (0.65) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL23871953 0.76 CYP2C19 (0.81) ALDH1A1HPGDKDM4EGAACA12
SCHEMBL455614 0.75 ALDH1A1 (0.76) ALDH1A1HPGDKDM4EGAACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392680-B1 SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 BAYER SCHERING PHARMA AG (DE) 2009-07-22 EP disclosed
EP-1392680-A2 SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 SCHERING AKTIENGESELLSCHAFT (DE) 2004-03-03 EP disclosed
WO-2002090352-A2 SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 SCHERING AKTIENGESELLSCHAFT (DE) 2002-11-14 WO disclosed