Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035453 | 0.92 | BCHE (0.47) | CCR3MEN1KMT2ALMNAACHE | |
| SCHEMBL4040634 | 0.79 | BCHE (0.44) | CCR3KMT2AACHEFAAHALDH1A1 | |
| SCHEMBL1801528 | 0.78 | CXCR3 (0.57) | MEN1KMT2ACYP2D6SIGMAR1ALDH1A1 | |
| SCHEMBL4039209 | 0.78 | CXCR3 (0.38) | KMT2AL3MBTL1 | |
| SCHEMBL2940834 | 0.78 | CXCR3 (0.38) | KMT2AL3MBTL1 | |
| SCHEMBL1801540 | 0.78 | CYP2D6 (0.41) | MEN1KMT2ASMN1; SMN2LMNACYP2D6 | |
| SCHEMBL2940899 | 0.78 | CYP2D6 (0.41) | MEN1KMT2ASMN1; SMN2LMNACYP2D6 | |
| SCHEMBL2940902 | 0.78 | CYP2D6 (0.41) | MEN1KMT2ASMN1; SMN2LMNACYP2D6 | |
| SCHEMBL3914967 | 0.78 | FAAH (0.52) | CYP2D6CYP2C19MAPTFAAHALDH1A1 | |
| SCHEMBL2933989 | 0.78 | CYP2D6 (0.54) | MEN1KMT2ASMN1; SMN2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | disclosed |