SCHEMBL4032545

SCHEMBL4032545

Cc1cccnc1CN(CCCCNC(=O)OC(C)(C)C)CCc1nccs1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
CYP3A4 P08684 2/20 0.38
CXCR4 P61073 2/20 0.37
METAP1 P53582 1/20 0.37
DRD2 P14416 3/20 0.37
TSHR P16473 1/20 0.36
KDM4E B2RXH2 1/20 0.35
CA12 O43570 3/20 0.35
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
CA9 Q16790 3/20 0.35
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
STING1 Q86WV6 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CKS1B P61024 1/20 0.34
SKP1 P63208 1/20 0.34
SKP2 Q13309 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2083428 0.84 CYP3A4 (0.43) L3MBTL1CYP3A4CXCR4DRD2TSHR
SCHEMBL4032836 0.82 CXCR4 (0.40) L3MBTL1CYP3A4CXCR4DRD2TSHR
SCHEMBL4039491 0.82 CYP3A4 (0.44) L3MBTL1CYP3A4CXCR4DRD2TSHR
SCHEMBL4035412 0.82 DRD2 (0.42) L3MBTL1CYP3A4CXCR4DRD2TSHR
SCHEMBL2085983 0.81 CXCR4 (0.43) L3MBTL1CYP3A4CXCR4METAP1TSHR
SCHEMBL2086065 0.78 CXCR4 (0.41) L3MBTL1CYP3A4CXCR4DRD2KDM4E
SCHEMBL4039107 0.78 CXCR4 (0.49) CXCR4CHRM2CHRM4CHRM5CHRM1
SCHEMBL4035655 0.77 DRD2 (0.39) L3MBTL1CYP3A4CXCR4DRD2KDM4E
SCHEMBL28231828 0.76 L3MBTL1 (0.51) L3MBTL1CYP3A4METAP1CA12CA1
SCHEMBL2081783 0.75 BCHE (0.48) CXCR4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613613-A4 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2009-03-25 EP disclosed
EP-1613613-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-01-11 EP disclosed
WO-2004091518-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2004-10-28 WO disclosed