SCHEMBL4039491

SCHEMBL4039491

Cc1cccnc1CN(CCCCNC(=O)OC(C)(C)C)CCc1cnccn1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.44
DRD2 P14416 3/20 0.38
CXCR4 P61073 1/20 0.37
TSHR P16473 1/20 0.36
CKS1B P61024 1/20 0.35
SKP1 P63208 1/20 0.35
SKP2 Q13309 1/20 0.35
KDM4E B2RXH2 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KMT2A Q03164 1/20 0.35
IDO1 P14902 1/20 0.35
STING1 Q86WV6 1/20 0.35
CA12 O43570 3/20 0.35
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
CA9 Q16790 3/20 0.35
NAMPT P43490 1/20 0.35
STK17B O94768 1/20 0.34
STK17A Q9UEE5 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4032836 0.88 CXCR4 (0.40) CYP3A4DRD2CXCR4TSHRKDM4E
SCHEMBL4035412 0.87 DRD2 (0.42) CYP3A4DRD2CXCR4TSHRCKS1B
SCHEMBL2083428 0.84 CYP3A4 (0.43) CYP3A4DRD2CXCR4TSHRCKS1B
SCHEMBL4032545 0.82 L3MBTL1 (0.40) CYP3A4DRD2CXCR4TSHRCKS1B
SCHEMBL2084285 0.82 CXCR4 (0.49) CYP3A4CXCR4TSHRCKS1BSKP1
SCHEMBL2085143 0.78 CYP3A4 (0.42) CYP3A4CXCR4TSHRCKS1BSKP1
SCHEMBL2086065 0.78 CXCR4 (0.41) CYP3A4DRD2CXCR4CKS1BSKP1
SCHEMBL2081783 0.75 BCHE (0.48) CXCR4KDM4E
SCHEMBL4035655 0.75 DRD2 (0.39) CYP3A4DRD2CXCR4CKS1BSKP1
SCHEMBL4035993 0.75 CYP3A4 (0.47) CYP3A4TSHRKDM4EL3MBTL1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613613-A4 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2009-03-25 EP disclosed
EP-1613613-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-01-11 EP disclosed
WO-2004091518-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2004-10-28 WO disclosed