Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038485 | 0.88 | TUBB4A (0.40) | TYMSTGFBR1TGFBR2ALDH1A1GRM4 | |
| SCHEMBL4035517 | 0.86 | TYMS (0.37) | TYMSTGFBR1TGFBR2ALDH1A1GRM4 | |
| SCHEMBL4042410 | 0.85 | PDE2A (0.42) | TGFBR1TGFBR2ALDH1A1TUBB4ATUBB | |
| SCHEMBL2053003 | 0.76 | PTGS2 (0.40) | TYMSTGFBR1TGFBR2ALDH1A1GRM4 | |
| SCHEMBL4043268 | 0.76 | PKN1 (0.36) | TGFBR1TGFBR2GRM4TUBB4ATUBB | |
| SCHEMBL4036370 | 0.74 | PARP1 (0.37) | TGFBR1TGFBR2ALDH1A1HPGD | |
| SCHEMBL4036538 | 0.74 | JAK2 (0.48) | TGFBR1ALDH1A1GRM4TUBB4ATUBB | |
| SCHEMBL4033058 | 0.74 | TYMS (0.37) | TYMSTGFBR1TGFBR2ALDH1A1RAB9A | |
| SCHEMBL4036827 | 0.74 | KDM4E (0.43) | TYMSTGFBR1TGFBR2ALDH1A1GRM4 | |
| SCHEMBL4033177 | 0.73 | KIF11 (0.42) | TGFBR1ALDH1A1GRM4POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |