Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036370 | 0.88 | PARP1 (0.37) | ALDH1A1HPGDTGFBR1TGFBR2RPS6KB1 | |
| SCHEMBL4036827 | 0.87 | KDM4E (0.43) | TYMSRAB9AALDH1A1HPGDNPC1 | |
| SCHEMBL4043268 | 0.87 | PKN1 (0.36) | RAB9ANPC1TGFBR1TGFBR2GRM4 | |
| SCHEMBL4033058 | 0.87 | TYMS (0.37) | TYMSRAB9AALDH1A1NPC1TGFBR1 | |
| SCHEMBL4033159 | 0.86 | TYMS (0.37) | TYMSRAB9ALMNAALDH1A1HPGD | |
| SCHEMBL4033177 | 0.86 | KIF11 (0.42) | LMNAALDH1A1TGFBR1GRM4POLB | |
| SCHEMBL4035502 | 0.86 | TUBB4A (0.39) | LMNAALDH1A1JAK2 | |
| SCHEMBL4036538 | 0.85 | JAK2 (0.48) | RAB9ALMNAALDH1A1NPC1TGFBR1 | |
| SCHEMBL4035416 | 0.85 | RHEB (0.43) | RPS6KB1JAK2MAPK14 | |
| SCHEMBL4207716 | 0.83 | MAPT (0.42) | RAB9ALMNAALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |