Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043268 | 0.88 | PKN1 (0.36) | PARP1JAK2PKN1PKN2TGFBR1 | |
| SCHEMBL4036827 | 0.88 | KDM4E (0.43) | PARP1TGFBR1TGFBR2ALDH1A1KDM4E | |
| SCHEMBL4033058 | 0.88 | TYMS (0.37) | JAK2PKN1PKN2TGFBR1TGFBR2 | |
| SCHEMBL4035517 | 0.88 | TYMS (0.37) | JAK2PKN1PKN2TGFBR1TGFBR2 | |
| SCHEMBL4035502 | 0.87 | TUBB4A (0.39) | PARP1JAK2PDE5AALDH1A1MEN1 | |
| SCHEMBL4036538 | 0.86 | JAK2 (0.48) | PARP1JAK2PKN1PKN2TGFBR1 | |
| SCHEMBL4034008 | 0.85 | LMNA (0.37) | PARP1JAK2PKN1PKN2TGFBR1 | |
| SCHEMBL4033177 | 0.85 | KIF11 (0.42) | PARP1TGFBR1ALDH1A1KDM4EMEN1 | |
| SCHEMBL4207716 | 0.84 | MAPT (0.42) | PARP1ALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL4033192 | 0.84 | PKN1 (0.38) | PARP1PLK4MAP4K4PIM1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |