Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | CCR1 | P32246 | 4/20 | 0.42 |
| ▸ | CCR5 | P51681 | 4/20 | 0.42 |
| ▸ | CCR8 | P51685 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032702 | 0.86 | TGFBR1 (0.46) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL16512102 | 0.78 | KDM4E (0.58) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL4034948 | 0.77 | TGFBR1 (0.45) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL12853981 | 0.74 | LMNA (0.68) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL4029533 | 0.72 | NPC1 (0.53) | KDM4ETP53SMN1; SMN2LMNAHSP90AA1 | |
| Phenanthroline SCHEMBL226209 | 0.72 | KDM4E (0.73) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL12854080 | 0.71 | MMP2 (0.58) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL30515654 | 0.70 | CCR1 (0.62) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL2922581 | 0.70 | CCR1 (0.62) | KDM4ECCR1CCR5CCR8TP53 | |
| SCHEMBL1282008 | 0.70 | CCR1 (0.75) | KDM4ECCR1CCR5CCR8TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-B1 | NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | PFIZER PROD INC (US) | 2009-04-29 | — | — | EP | claimed |