Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033608 | 0.87 | ALOX15 (0.41) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL6209492 | 0.81 | ALOX15 (0.41) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL4032732 | 0.79 | GAA (0.54) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL1386085 | 0.77 | MAPK1 (0.51) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL4033612 | 0.76 | RAB9A (0.38) | ALDH1A1MAPTHTTLMNAKMT2A | |
| SCHEMBL1381941 | 0.73 | PKM (0.54) | GAAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL6209732 | 0.72 | ALDH1A1 (0.45) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL4034713 | 0.71 | ALDH1A1 (0.44) | TP53ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4034709 | 0.71 | GAA (0.56) | TP53GAAALDH1A1POLBMAPT | |
| SCHEMBL1385884 | 0.67 | MAPK1 (0.59) | GAAALDH1A1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |