Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035481 | 0.90 | TSHR (0.49) | TSHRNAMPTALDH1A1CHRM1MMP1 | |
| SCHEMBL4037487 | 0.88 | MAPT (0.49) | TSHRNAMPTALDH1A1LMNAPKM | |
| SCHEMBL4038385 | 0.86 | ALDH1A1 (0.57) | ALDH1A1CHRM1PKM | |
| SCHEMBL4042256 | 0.85 | POLB (0.46) | ALDH1A1CHRM1MMP1MMP3MMP7 | |
| SCHEMBL4042590 | 0.85 | CHRM1 (0.43) | NAMPTALDH1A1CHRM1LMNA | |
| SCHEMBL4033849 | 0.85 | MAPK1 (0.53) | TSHRALDH1A1LMNA | |
| SCHEMBL4033312 | 0.85 | P2RX7 (0.45) | — | |
| SCHEMBL4035457 | 0.84 | CHRM5 (0.45) | NAMPTCHRM1MMP1MMP3MMP7 | |
| SCHEMBL4033365 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1CHRM1MMP1MMP3MMP7 | |
| SCHEMBL4034711 | 0.81 | KMT2A (0.41) | ALDH1A1CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |