Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033852 | 0.90 | TSHR (0.46) | TSHRNAMPTLMNAALDH1A1CHRM1 | |
| SCHEMBL4037487 | 0.86 | MAPT (0.49) | TSHRKDM4ENAMPTLMNAALDH1A1 | |
| SCHEMBL4038385 | 0.86 | ALDH1A1 (0.57) | KDM4EALDH1A1USP2CHRM1KMT2A | |
| SCHEMBL4042590 | 0.85 | CHRM1 (0.43) | NAMPTLMNAALDH1A1USP2CHRM1 | |
| SCHEMBL4042256 | 0.85 | POLB (0.46) | LMNAALDH1A1USP2CHRM1MMP1 | |
| SCHEMBL4035477 | 0.85 | MAPK1 (0.53) | TSHRNAMPTLMNAALDH1A1KMT2A | |
| SCHEMBL4033312 | 0.85 | P2RX7 (0.45) | L3MBTL1POLB | |
| SCHEMBL4035457 | 0.83 | CHRM5 (0.45) | NAMPTLMNACHRM1MMP1MMP3 | |
| SCHEMBL4033365 | 0.82 | SMN1; SMN2 (0.47) | LMNAALDH1A1CHRM1KMT2ASMN1; SMN2 | |
| SCHEMBL4034711 | 0.81 | KMT2A (0.41) | KDM4ELMNAALDH1A1USP2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |