Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034918 | 0.88 | LPAR1 (0.45) | LPAR1TP53GAAS1PR1S1PR3 | |
| SCHEMBL4028121 | 0.85 | LPAR1 (0.44) | LPAR1LPAR3 | |
| SCHEMBL4033561 | 0.83 | LPAR1 (0.42) | LPAR1LPAR3 | |
| SCHEMBL4031584 | 0.82 | LPAR1 (0.43) | LPAR1S1PR1LPAR3 | |
| SCHEMBL4031919 | 0.80 | TRPA1 (0.50) | LPAR1S1PR3LPAR3S1PR4 | |
| SCHEMBL4036870 | 0.79 | MAPK1 (0.42) | LPAR1LPAR3CNR2 | |
| SCHEMBL4030691 | 0.78 | LPAR1 (0.41) | LPAR1TP53LPAR3 | |
| SCHEMBL4027903 | 0.78 | HTT (0.45) | LPAR1TP53GAALPAR3CNR2 | |
| SCHEMBL4034953 | 0.76 | LPAR1 (0.52) | LPAR1S1PR1S1PR3LPAR3LTB4R2 | |
| SCHEMBL4034077 | 0.76 | HDAC3 (0.41) | LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |