Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | EP300 | Q09472 | 6/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.36 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028121 | 0.88 | LPAR1 (0.44) | TRPA1LPAR1LPAR3ALDH1A1ABCC3 | |
| SCHEMBL4036790 | 0.87 | TRPA1 (0.46) | TRPA1EP300LPAR1LPAR3ALDH1A1 | |
| SCHEMBL4031683 | 0.85 | TRPA1 (0.43) | TRPA1EP300LPAR1LPAR3S1PR3 | |
| SCHEMBL4033561 | 0.85 | LPAR1 (0.42) | TRPA1LPAR1LPAR3ALDH1A1ABCC3 | |
| SCHEMBL4031584 | 0.84 | LPAR1 (0.43) | TRPA1LPAR1LPAR3ALDH1A1ABCC3 | |
| SCHEMBL4036870 | 0.82 | MAPK1 (0.42) | LPAR1LPAR3ALDH1A1LMNA | |
| SCHEMBL4030691 | 0.80 | LPAR1 (0.41) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4033953 | 0.80 | LPAR1 (0.41) | LPAR1LPAR3S1PR3S1PR4 | |
| SCHEMBL4027903 | 0.80 | HTT (0.45) | LPAR1LPAR3ALDH1A1BRD4STAT3 | |
| SCHEMBL4034077 | 0.78 | HDAC3 (0.41) | LPAR1LPAR3BRD4STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |