Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028121 | 0.91 | LPAR1 (0.44) | LPAR1LPAR3TDP1ABCC3ABCC4 | |
| SCHEMBL4034077 | 0.88 | HDAC3 (0.41) | LPAR1LPAR3STAT3TRPM8KMT2A | |
| SCHEMBL4031584 | 0.87 | LPAR1 (0.43) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4032476 | 0.86 | LPAR1 (0.43) | LPAR1LPAR3KMT2AMEN1KDM4E | |
| SCHEMBL4031919 | 0.85 | TRPA1 (0.50) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4030691 | 0.85 | LPAR1 (0.41) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL4036870 | 0.84 | MAPK1 (0.42) | LPAR1LPAR3KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4030969 | 0.84 | LPAR1 (0.38) | LPAR1LPAR3STAT3KMT2AMEN1 | |
| SCHEMBL4033953 | 0.83 | LPAR1 (0.41) | LPAR1LPAR3 | |
| SCHEMBL4027903 | 0.83 | HTT (0.45) | LPAR1LPAR3STAT3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |