Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034366 | 0.89 | AKR1C3 (0.43) | MAPK1LMNAKMT2ALPAR1LPAR3 | |
| SCHEMBL15437794 | 0.87 | LPAR1 (0.41) | MAPK1LMNAKMT2ALPAR1LPAR3 | |
| SCHEMBL4034300 | 0.87 | LPAR1 (0.41) | MAPK1LMNAKMT2ALPAR1LPAR3 | |
| SCHEMBL4028121 | 0.87 | LPAR1 (0.44) | LMNAKMT2ALPAR1LPAR3POLB | |
| SCHEMBL4033561 | 0.84 | LPAR1 (0.42) | KMT2ALPAR1LPAR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4031919 | 0.82 | TRPA1 (0.50) | LMNALPAR1LPAR3ALDH1A1 | |
| SCHEMBL4030691 | 0.79 | LPAR1 (0.41) | MAPK1LPAR1LPAR3MMP13 | |
| SCHEMBL4033953 | 0.79 | LPAR1 (0.41) | LPAR1LPAR3CNR2 | |
| SCHEMBL4027903 | 0.79 | HTT (0.45) | LMNALPAR1LPAR3RAB9AALDH1A1 | |
| SCHEMBL4034077 | 0.77 | HDAC3 (0.41) | KMT2ALPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |