Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2472816 | 0.86 | GPBAR1 (0.57) | KMT2AMEN1GAATSHRPOLB | |
| SCHEMBL2473629 | 0.85 | KMT2A (0.51) | CACNA1FABCB1CACNA1DCACNA1SCACNA1C | |
| SCHEMBL1260319 | 0.85 | KMT2A (0.66) | KMT2AMEN1GAATSHRPOLB | |
| SCHEMBL2472330 | 0.83 | RAB9A (0.53) | CACNA1FABCB1CACNA1DCACNA1SCACNA1C | |
| SCHEMBL2472321 | 0.79 | KMT2A (0.47) | KMT2AMEN1GAATSHRPOLB | |
| SCHEMBL2471701 | 0.77 | GPBAR1 (0.54) | KMT2AMEN1GAATSHRPOLB | |
| SCHEMBL4034243 | 0.75 | KMT2A (0.49) | CACNA1FABCB1CACNA1DCACNA1SCACNA1C | |
| SCHEMBL27715415 | 0.74 | HTT (0.47) | CACNA1FABCB1CACNA1DCACNA1SCACNA1C | |
| SCHEMBL3975091 | 0.74 | HTT (0.54) | CACNA1FABCB1CACNA1DCACNA1SCACNA1C | |
| SCHEMBL2473847 | 0.72 | GPBAR1 (0.56) | TSHRPOLBMAPK1GPBAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-B1 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-05 | — | — | EP | disclosed |
| US-7414061-B2 | Aryl-isoxazol-4-yl-imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-20080004263-A1 | Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof | ARENA PHARMACEUTICALS, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004263-A1 | Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof | ARENA PHARMACEUTICALS, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004263-A1 | Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof | ARENA PHARMACEUTICALS, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20070161654-A1 | Aryl-isoxazol-4-yl-imidazole derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-12 | — | — | US | disclosed |
| WO-2005087765-A1 | LIGANDS OF FOLLICLE STIMULATING HORMONE RECEPTOR AND METHODS OF USE THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161654-A1 | Aryl-isoxazol-4-yl-imidazole derivatives | GABRA5, GABRA4, GABRA1 | CACNA1F 411/4885ABCB1 686/4885CACNA1D 308/4885 |
| US-20080004263-A1 | Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof | FSHR, GNRHR, LHCGR | CACNA1F 3746/4885ABCB1 3924/4885CACNA1D 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.