Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942914 | 0.90 | HTR6 (0.41) | BRD4PTGS2AURKAAURKBPOLB | |
| SCHEMBL3942093 | 0.82 | MEN1 (0.42) | BRD4PTGS2MAPTMAPK8 | |
| SCHEMBL3942800 | 0.82 | ATIC (0.41) | BRD4CYP19A1PADI4 | |
| SCHEMBL3942147 | 0.81 | BRD4 (0.52) | BRD4CA1CA2POLBMAPT | |
| SCHEMBL3952131 | 0.79 | SERPINE1 (0.51) | BRD4MAPT | |
| SCHEMBL3942565 | 0.77 | PTGS2 (0.44) | BRD4PTGS2AURKAAURKB | |
| SCHEMBL3951863 | 0.76 | ALDH1A1 (0.43) | CA12CA1CA2CA4CA6 | |
| SCHEMBL3942059 | 0.75 | CA1 (0.51) | BRD4PTGS2CA12CA1CA2 | |
| SCHEMBL3944908 | 0.75 | SERPINE1 (0.52) | BRD4POLBMAPTTDP1 | |
| SCHEMBL3945864 | 0.74 | BRD4 (0.52) | BRD4CA1CA2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-B1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-04-22 | — | — | EP | claimed |