Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040159 | 0.78 | LCK (0.38) | LCKPIK3CD | |
| SCHEMBL4036111 | 0.76 | LCK (0.42) | LCKSRC | |
| SCHEMBL4042263 | 0.73 | LCK (0.47) | LCKSRC | |
| SCHEMBL8469801 | 0.73 | LCK (0.50) | LCK | |
| SCHEMBL6626588 | 0.73 | LCK (0.43) | LCK | |
| SCHEMBL7983005 | 0.73 | LCK (0.50) | LCK | |
| SCHEMBL7983561 | 0.72 | LCK (0.47) | LCK | |
| SCHEMBL4041190 | 0.72 | LCK (0.51) | LCKSRC | |
| SCHEMBL4042434 | 0.71 | LCK (0.41) | LCK | |
| SCHEMBL4043255 | 0.71 | NOS1 (0.40) | LCKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |