Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.37 |
| ▸ | LCK | P06239 | 8/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040159 | 0.94 | LCK (0.38) | NOS1NOS2PIK3CDLCK | |
| SCHEMBL4043849 | 0.80 | LCK (0.43) | PIK3CDLCKFGFR1 | |
| SCHEMBL4038275 | 0.76 | LCK (0.40) | LCK | |
| SCHEMBL4042263 | 0.75 | LCK (0.47) | LCKFGFR1 | |
| SCHEMBL4036111 | 0.73 | LCK (0.42) | LCKFGFR1 | |
| SCHEMBL8472491 | 0.72 | LCK (0.44) | LCKFGFR1 | |
| SCHEMBL4036381 | 0.71 | LCK (0.36) | PIK3CDLCK | |
| SCHEMBL8469310 | 0.70 | LCK (0.46) | LCKFGFR1 | |
| SCHEMBL4042434 | 0.70 | LCK (0.41) | LCKFGFR1 | |
| SCHEMBL7979958 | 0.69 | LCK (0.56) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |