Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561971 | 0.79 | PTGS2 (0.40) | ALDH1A1LMNAPKMMEN1KMT2A | |
| SCHEMBL9131822 | 0.75 | MEN1 (0.57) | ALDH1A1LMNASMN1; SMN2TDP1MEN1 | |
| SCHEMBL8349568 | 0.74 | ALDH1A1 (0.79) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL3778345 | 0.72 | ALDH1A1 (0.55) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL9229237 | 0.72 | IKBKB (0.43) | ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL606283 | 0.71 | ALDH1A1 (0.68) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL301798 | 0.71 | ALDH1A1 (0.68) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL10453840 | 0.70 | ALDH1A1 (0.96) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL301743 | 0.70 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2KDM4EPKM | |
| SCHEMBL8851636 | 0.70 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |