SCHEMBL40376

SCHEMBL40376

O=C(Oc1c(F)c(F)c(F)c(F)c1F)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NR3C1 P04150 1/20 0.33
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18432742 0.89 TAS1R3 (0.33) TSHRSMN1; SMN2NR3C1
SCHEMBL16475482 0.89 NR3C1 (0.32) TSHRSMN1; SMN2NR3C1
SCHEMBL24270802 0.86 TSHR (0.33) TSHRSMN1; SMN2
SCHEMBL22642564 0.84 TSHR (0.32) TSHRSMN1; SMN2
SCHEMBL20047250 0.83 RECQL (0.30) RECQL
SCHEMBL19105207 0.83 NR3C1 (0.35) TSHRSMN1; SMN2NR3C1CA1CA2
SCHEMBL13917867 0.83 NR3C1 (0.35) TSHRSMN1; SMN2NR3C1CA1CA2
SCHEMBL319016 0.82 CA1 (0.39) NR3C1CA1CA2
SCHEMBL1401784 0.81 TSHR (0.33) TSHRSMN1; SMN2NR3C1
SCHEMBL21389209 0.80 DGAT1 (0.34) TSHRSMN1; SMN2NR3C1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3029 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121874958-B Antibacterial thermal insulation fiber based on thermal insulation material and preparation method thereof BOSIDENG DOWN WEAR Co.,Ltd. (CN) 2026-05-26 CN claimed
EP-3811977-B1 METHOD FOR SYNTHESIS OF REACTIVE CONJUGATE CLUSTERS IONIS PHARMACEUTICALS INC (US) 2025-12-03 EP claimed
CN-119638592-A Preparation method of cable-marlutide side chain 苏州昊帆生物股份有限公司 2025-03-18 CN claimed
CN-119039583-B Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof 浙江农林大学 2025-03-11 CN claimed
CN-119108555-A Sodium-electricity coal-based hard carbon negative electrode material and preparation method thereof 洛阳新能源科技发展集团有限公司 2024-12-10 CN claimed
CN-119039583-A Side-chain base biodegradable polyester amide with stereocomplex crystallization performance and enzymatic preparation method thereof 浙江农林大学 2024-11-29 CN claimed
CN-118516856-A Transparent conductive shielding film with high flexibility and preparation method thereof 深圳市海普睿能科技有限公司 2024-08-20 CN claimed
CN-118290730-A Cyclopropene cationic polymer, and preparation method and application thereof 华南理工大学 2024-07-05 CN claimed
CN-118271335-A Accurate positioning method for abasic site in genomic DNA 北京大学 2024-07-02 CN claimed
US-20240150390-A1 NOVEL METHOD FOR PRODUCING ANTIBODY-IMMUNOSTIMULATOR CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-05-09 US claimed
US-20040225097-A1 NOVEL PREPARATION METHOD OF PEG-MALEIMIDE DERIVATIVES SUNBIO INC. (KR) 2004-11-11 US claimed
US-20040115165-A1 Bifunctional polyethylene glycol derivatives SUN BIO, INC. 2004-06-17 US claimed
US-20040010029-A1 Indole derivatives as interleukin -4 gene expression inhibitors AVENTIS PHARMACEUTICALS INC. 2004-01-15 US claimed
WO-2003091215-A1 3-SUBSTITUTED AMINO-1H-INDOLE-2-CARBOXYLIC ACID AND 3-SUBSTITUTED AMINO-BENZO’ B! THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS INTERIEUKIN-4 GENE EXPRESSION INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2003-11-06 WO claimed
US-6562944-B1 Generation of preferential halogen compound; obtain carboxylic acid mixture, incubabte with halogenated compound, recover by-product LEXICON PHARMACEUTICALS 2003-05-13 US claimed
EP-0749446-B1 HIGHLY REACTIVE ESTERS OF CARBOXY POLYSACCHARIDES AND NOVEL CARBOXY POLYSACCHARIDES DERIVED THEREFROM FIDIA ADVANCED BIOPOLYMERS SRL (IT) 1999-11-24 EP claimed
US-5856299-A ESTERIFICATION WITH ALCOHOL FIDIA ADVANCED BIOPOLYMERS S.R.L. (IT) 1999-01-05 US claimed
EP-0749446-A1 HIGHLY REACTIVE ESTERS OF CARBOXY POLYSACCHARIDES AND NOVEL CARBOXY POLYSACCHARIDES DERIVED THEREFROM FIDIA ADVANCED BIOPOLYMERS S.R.L. (IT) 1996-12-27 EP claimed
WO-1995024429-A1 HIGHLY REACTIVE ESTERS OF CARBOXY POLYSACCHARIDES AND NOVEL CARBOXY POLYSACCHARIDES DERIVED THEREFROM FIDIA ADVANCED BIOPOLYMERS S.R.L. (IT) 1995-09-14 WO claimed
US-4978744-A Synthesis of dolastatin 10 ARIZONA BOARD OF REGENTS (US) 1990-12-18 US claimed