Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1373496 | 0.73 | HTR3A (0.56) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1376583 | 0.71 | HTR3A (0.58) | — | |
| SCHEMBL29733664 | 0.71 | KDM4E (0.71) | MAPTNPC1RAB9ASMN1; SMN2PDGFRB | |
| SCHEMBL4094356 | 0.71 | KDM4E (0.71) | MAPTNPC1RAB9ASMN1; SMN2PDGFRB | |
| SCHEMBL10509392 | 0.71 | ALDH1A1 (0.57) | MAPTALDH1A1KMT2ANPC1HTT | |
| SCHEMBL1550263 | 0.68 | PTGS2 (0.52) | MAPTALDH1A1KMT2ANPC1HTT | |
| SCHEMBL4193491 | 0.68 | NR3C1 (0.41) | ALDH1A1KMT2ANPC1HTTRAB9A | |
| SCHEMBL10079858 | 0.67 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL2996492 | 0.66 | MAPK14 (0.56) | MAPTALDH1A1KMT2ANPC1HTT | |
| Hydrochloric Acid SCHEMBL5402735 | 0.65 | MAPK14 (0.55) | MAPTALDH1A1KMT2ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023411-A1 | COMPOSITIONS AND METHODS FOR TREATING OR CONTROLLING ANTERIOR- AND POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |