Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916351 | 0.90 | GAA (0.34) | FEN1GAAKMT2ATSHRLMNA | |
| SCHEMBL4032369 | 0.89 | GAA (0.32) | FEN1GAAKMT2ATSHRLMNA | |
| SCHEMBL4036440 | 0.87 | TSHR (0.34) | GAAKMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL4035595 | 0.87 | CCR5 (0.38) | FEN1TSHROPRM1OPRL1DPP4 | |
| SCHEMBL3925602 | 0.87 | GAA (0.36) | GAAKMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL4037470 | 0.85 | GAA (0.44) | GAAKMT2ATSHRLMNAALDH1A1 | |
| SCHEMBL4035028 | 0.85 | FAAH (0.38) | GAATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4038594 | 0.84 | P2RX7 (0.33) | GAAKMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL4040064 | 0.83 | CHRM3 (0.39) | FEN1GAAKMT2AOPRM1OPRL1 | |
| Benzamide SCHEMBL4033416 | 0.82 | DPP4 (0.33) | GAAKMT2ATSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |