Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800279 | 0.87 | CES2 (0.39) | PBRM1CASP1CES2CES1IDO1 | |
| SCHEMBL6818860 | 0.85 | PBRM1 (0.41) | PBRM1CASP1KMT2AATMSLC2A1 | |
| SCHEMBL8676513 | 0.83 | PBRM1 (0.43) | PBRM1CASP1KMT2AATMSLC2A1 | |
| SCHEMBL201397 | 0.82 | HSD17B1 (0.41) | PBRM1CES2CES1PARP1 | |
| SCHEMBL27630874 | 0.81 | ALDH1A1 (0.46) | KMT2ASLC2A1CES2CES1GAA | |
| SCHEMBL7820374 | 0.81 | DPP4 (0.48) | CASP1SLC2A1CES2CES1GAA | |
| SCHEMBL4026715 | 0.80 | POLB (0.42) | PBRM1CASP1CES2CES1GAA | |
| Hydrochloric Acid SCHEMBL8380885 | 0.80 | PBRM1 (0.41) | PBRM1CASP1KMT2AATMSLC2A1 | |
| SCHEMBL14661433 | 0.80 | DGAT1 (0.39) | PBRM1CASP1CES2CES1IDO1 | |
| SCHEMBL3101770 | 0.79 | NOTUM (0.37) | KMT2ASLC2A1CES2CES1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846410-B1 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1846410-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | Bristol-Myers Squibb Company (US) | 2007-10-24 | — | — | EP | disclosed |
| US-7238702-B2 | Dihydroquinazolinones as 5HT modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| WO-2006086464-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |
| US-20060178386-A1 | Dihydroquinazolinones as 5HT modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178386-A1 | Dihydroquinazolinones as 5HT modulators | HTR3B, HTR2C, HTR2B | PBRM1 2795/4885CASP1 3669/4885KMT2A 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.