SCHEMBL4043336

SCHEMBL4043336

O=C(NC1CCCC1)C(CCc1ccccc1)C1(c2cccc(O)c2)Nc2ccccc2N1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
OPRD1 P41143 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
EPHX1 P07099 4/20 0.40
EPHX2 P34913 3/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
TP53 P04637 1/20 0.40
TSHR P16473 1/20 0.40
OPRM1 P35372 3/20 0.40
OPRK1 P41145 3/20 0.40
MMP2 P08253 4/20 0.39
MMP3 P08254 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HTT P42858 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4044238 0.87 CTSD (0.42) SMN1; SMN2EPHX1EPHX2NPC1RAB9A
SCHEMBL4043346 0.83 POLB (0.42) SMN1; SMN2EPHX1RAB9ATSHRALDH1A1
SCHEMBL4035090 0.82 ALDH1A1 (0.43) SMN1; SMN2EPHX1EPHX2NPC1RAB9A
SCHEMBL4038935 0.78 METAP2 (0.43) SMN1; SMN2TSHRMMP2MMP3ALDH1A1
SCHEMBL4036682 0.76 METAP2 (0.44) MMP2MMP3ALDH1A1HTTHPGD
SCHEMBL4040042 0.75 MEN1 (0.46) SMN1; SMN2EPHX2NPC1RAB9ATP53
SCHEMBL4038962 0.74 MASP2 (0.42) SMN1; SMN2TP53TSHRALDH1A1HTT
SCHEMBL4035018 0.73 ACE (0.41) SMN1; SMN2TSHROPRM1OPRK1ALDH1A1
SCHEMBL4036794 0.72 EPHX2 (0.44) SMN1; SMN2EPHX1EPHX2NPC1RAB9A
SCHEMBL4041615 0.72 CNR1 (0.41) TSHROPRM1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP claimed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO claimed
EP-3043865-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2016-07-20 EP disclosed
WO-2015036442-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2015-03-19 WO disclosed
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed