Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046143 | 0.92 | KDM4E (0.50) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4045972 | 0.85 | ALDH1A1 (0.48) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4045394 | 0.82 | NOTUM (0.48) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4044717 | 0.81 | NOTUM (0.56) | KDM4EGAAALDH1A1HPGDNOTUM | |
| SCHEMBL4044784 | 0.80 | HPGD (0.45) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4046992 | 0.78 | ALDH1A1 (0.47) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL5424122 | 0.77 | KDM4E (0.44) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4053059 | 0.76 | NOTUM (0.50) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4044561 | 0.74 | PPARG (0.50) | KDM4EGLAGAAALDH1A1HPGD | |
| SCHEMBL4044268 | 0.74 | CACNA1B (0.45) | KDM4EGAAALDH1A1HPGDNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603921-B1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-17 | — | — | EP | disclosed |
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | IL1B, IL1A, TNF | KDM4E 3071/4885GLA 1728/4885GAA 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.