Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 4/20 | 0.41 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043815 | 0.93 | PPARG (0.49) | PPARGMAOBMEN1HSP90AA1KMT2A | |
| SCHEMBL4044784 | 0.90 | HPGD (0.45) | PPARGMAOBMEN1KMT2AL3MBTL1 | |
| SCHEMBL4045972 | 0.87 | ALDH1A1 (0.48) | PPARGMAOBMEN1HSP90AA1KMT2A | |
| SCHEMBL4047340 | 0.85 | PPARG (0.44) | PPARGMAOBMEN1HSP90AA1KMT2A | |
| SCHEMBL4048780 | 0.84 | ALDH1A1 (0.50) | MAOBMEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL5422453 | 0.82 | ALDH1A1 (0.50) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL4046992 | 0.80 | ALDH1A1 (0.47) | PPARGMAOBMEN1HSP90AA1KMT2A | |
| SCHEMBL4045388 | 0.79 | ALDH1A1 (0.49) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5424122 | 0.78 | KDM4E (0.44) | PPARGMAOBMEN1HSP90AA1KMT2A | |
| SCHEMBL4048452 | 0.78 | MEN1 (0.43) | PPARGMAOBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-03-30 | — | — | US | claimed |
| EP-1603921-B1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-06-17 | — | — | EP | disclosed |
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069149-A1 | Thiadibenzoazulene derivatives for the treatment of inflammatory diseases | IL1B, IL1A, TNF | PPARG 296/4885MAOB 1459/4885MEN1 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.