Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL4044054

CO[C@@H]1CCNC1.O=C(O)C(F)(F)F

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRNB3 Q05901 1/20 0.35
CHRNA6 Q15825 1/20 0.35
SLC6A1 P30531 4/20 0.35
GABRA5 P31644 3/20 0.35
GABRB2 P47870 3/20 0.35
SLC6A11 P48066 3/20 0.35
SLC6A13 Q9NSD5 3/20 0.35
SLC6A12 P48065 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRA4 P48169 2/20 0.35
GABRR1 P24046 1/20 0.35
SSTR1 P30872 1/20 0.35
SSTR4 P31391 1/20 0.35
HRH4 Q9H3N8 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
PKM P14618 1/20 0.34
PRCP P42785 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5772837 1.00 CHRNB2 (0.35) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL1771251 0.90 SLC6A1 (0.42) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL2912962 0.89 GABRP (0.39) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL932729 0.85 CHRNB2 (0.34) CHRNB2CHRNA3CHRNA4PKM
Trifluoroacetic Acid SCHEMBL20576082 0.83 SLC6A1 (0.33) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL3338487 0.81 SLC6A4 (0.33) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL21063469 0.81 SLC6A1 (0.40) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Trifluoroacetic Acid SCHEMBL3338497 0.81 SLC6A4 (0.33) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL492237 0.80
SCHEMBL321509 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250313560-A1 Novel bicyclic benzylamido pyridine derivatives as SOS1 inhibitors BOEHRINGER INGELHEIM INT (DE) 2025-10-09 US disclosed
EP-3307741-B1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARIC M2 RECEPTOR Bayer Pharma AG (DE) 2020-10-28 EP disclosed
EP-3692991-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC M2 RECEPTOR Bayer Pharma Aktiengesellschaft (DE) 2020-08-12 EP disclosed
US-10435403-B2 Positive allosteric modulators of muscarinic M2 receptor BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2019-10-08 US disclosed
US-20180297994-A1 POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-10-18 US disclosed
EP-3307741-A1 POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR Bayer Pharma Aktiengesellschaft (DE) 2018-04-18 EP disclosed
WO-2016198342-A1 POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-15 WO disclosed
EP-1620437-B1 5,7-DIAMINOPYRAZOLO¬4,3-D PYRIMIDINES USEFUL IN THE TRAETMENT OF HYPERTENSION PFIZER LTD (GB) 2009-06-17 EP disclosed
US-20070270412-A1 NOVEL PHARMACEUTICALS PFIZER INC 2007-11-22 US disclosed
US-7262192-B2 Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors PFIZER INC. (US) 2007-08-28 US disclosed
US-7060836-B2 Lactams as tachykinin antagonists PFIZER, INC (US) 2006-06-13 US disclosed
CN-1780841-A 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the traetment of hypertension PFIZER LTD (GB) 2006-05-31 CN disclosed
US-20050043325-A1 Novel pharmaceuticals PFIZER INC 2005-02-24 US disclosed
EP-1456200-A1 LACTAMS AS TACHYKININ ANTAGONISTS Pfizer Limited (GB) 2004-09-15 EP disclosed
US-20040132710-A1 Lactams as tachkinin antagonists PFIZER INC. 2004-07-08 US disclosed
WO-2003051868-A1 LACTAMS AS TACHYKININ ANTAGONISTS PFIZER LIMITED (GB) 2003-06-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180297994-A1 POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR CHRM2, CHRM1, CHRM3 CHRNB2 27/4885CHRNA3 12/4885CHRNA4 15/4885
US-20050043325-A1 Novel pharmaceuticals ABCB11, PCSK9, SLC10A1 CHRNB2 3662/4885CHRNA3 3999/4885CHRNA4 4096/4885
US-20040132710-A1 Lactams as tachkinin antagonists PROKR1, TACR2, TACR1 CHRNB2 1211/4885CHRNA3 1726/4885CHRNA4 2210/4885
US-10435403-B2 Positive allosteric modulators of muscarinic M2 receptor CHRM2, CHRM1, CHRM3 CHRNB2 27/4885CHRNA3 12/4885CHRNA4 15/4885
US-20250313560-A1 Novel bicyclic benzylamido pyridine derivatives as SOS1 inhibitors SOS1, SOS2, RSU1 CHRNB2 3635/4885CHRNA3 3701/4885CHRNA4 4163/4885
US-20070270412-A1 NOVEL PHARMACEUTICALS ABCB11, PCSK9, SLC10A1 CHRNB2 3662/4885CHRNA3 3999/4885CHRNA4 4096/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.