Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31477659 | 0.90 | CYP2C19 (0.54) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL1573515 | 0.90 | CYP2C19 (0.54) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL5862223 | 0.90 | CYP2C19 (0.54) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL29770797 | 0.82 | CA12 (0.44) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL3375626 | 0.78 | MAPT (0.42) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL5862815 | 0.77 | MIF (0.49) | CYP2C19HIF1ACYP1A2MEN1GAA | |
| SCHEMBL6513375 | 0.77 | HIF1A (0.39) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL5860841 | 0.76 | ITGB1 (0.47) | CYP2C19HIF1ACA1RECQLMAPK1 | |
| SCHEMBL5634375 | 0.76 | CTSS (0.43) | CYP2C19HIF1AAKT1CA12CA1 | |
| SCHEMBL28754961 | 0.75 | CYP2C19 (0.51) | CYP2C19HIF1AAKT1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635641-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-7427637-B2 | Mitotic kinesin inhibitors | MERCK & CO. INC. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1635641-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20060142278-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2006-06-29 | — | — | US | disclosed |
| EP-1635641-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004112699-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142278-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18A | CYP2C19 4746/4885HIF1A 4022/4885AKT1 2955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.