Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038988 | 0.93 | LMNA (0.42) | LMNAPKMPOLBSLC6A9TSHR | |
| SCHEMBL4045126 | 0.77 | KMT2A (0.38) | — | |
| SCHEMBL6632666 | 0.77 | LMNA (0.47) | LMNAPKMPOLB | |
| SCHEMBL6653014 | 0.76 | PKM (0.47) | PKMPOLBTSHR | |
| SCHEMBL4044206 | 0.73 | KMT2A (0.42) | PKMPOLB | |
| SCHEMBL4038921 | 0.72 | AKR1C3 (0.46) | — | |
| SCHEMBL4047940 | 0.71 | LSS (0.37) | TSHR | |
| SCHEMBL4036996 | 0.71 | SMN1; SMN2 (0.39) | TSHR | |
| SCHEMBL4043222 | 0.71 | GBA1 (0.42) | LMNAPKMPOLB | |
| SCHEMBL4041706 | 0.71 | CSNK1E (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |