Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 12/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 4/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13964296 | 0.83 | MEN1 (0.35) | KMT2AMEN1CSNK1EMMP14ADAMTS5 | |
| SCHEMBL4043718 | 0.80 | CSNK1E (0.41) | KMT2AMEN1CSNK1E | |
| SCHEMBL6632666 | 0.79 | LMNA (0.47) | KMT2AMEN1KDM4E | |
| SCHEMBL6653014 | 0.78 | PKM (0.47) | KMT2AMEN1 | |
| SCHEMBL4044860 | 0.77 | LMNA (0.43) | — | |
| SCHEMBL4041706 | 0.77 | CSNK1E (0.42) | KMT2AMEN1CSNK1E | |
| SCHEMBL4040415 | 0.76 | KMT2A (0.41) | KMT2AMEN1CSNK1EKDM4E | |
| SCHEMBL4037674 | 0.76 | CSNK1E (0.42) | KMT2AMEN1CSNK1E | |
| SCHEMBL4044206 | 0.75 | KMT2A (0.42) | KMT2AMEN1CSNK1E | |
| SCHEMBL14394090 | 0.74 | CSNK1E (0.37) | CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |