Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038882 | 0.92 | PKM (0.45) | PKMTSHRMAPK1POLBMEN1 | |
| SCHEMBL4045126 | 0.78 | KMT2A (0.38) | MEN1KMT2A | |
| SCHEMBL6632666 | 0.78 | LMNA (0.47) | PKMPOLBMEN1KMT2ARAB9A | |
| SCHEMBL4044206 | 0.76 | KMT2A (0.42) | PKMPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL4044860 | 0.76 | LMNA (0.43) | PKMTSHRPOLB | |
| SCHEMBL4038921 | 0.75 | AKR1C3 (0.46) | KMT2A | |
| SCHEMBL4047940 | 0.74 | LSS (0.37) | TSHRKMT2A | |
| SCHEMBL4043222 | 0.74 | GBA1 (0.42) | PKMPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL4041706 | 0.74 | CSNK1E (0.42) | MEN1KMT2A | |
| SCHEMBL4041961 | 0.72 | PKM (0.47) | PKMTSHRMAPK1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |